"Pinata ill? Get the Doc to give them a bottle of this, I'm sure it will help. Having trouble finding it? Honey is the key."
Bottle of Medicine is a produce item that you can obtain by tinkering a jar of honey using Bart's Exchange's service. To obtain honey in the first place, you must build a Honey Hive which can be purchased in the Buildings section in Willy Builder's. Then, direct a Buzzlegum that is ready to produce to the Honey Hive, and they will produce a jar of honey. You can also simply buy a jar of honey from the produce section in Costolot's for 500 chocolate coins if you wish to skip this process.
While Medicine cannot actually cure an ill pinata, it can be used to:
Tame a Sour Crowla if it eats a bottle of medicine in all versions.
Drinking a bottle of medicine will help a Fizzlybear reach its romance requirements in Classic and Pocket Paradise.
Medicine will change the color of a Barkbark, Buzzenge, Buzzlegum, Cluckles, Fourheads, Kittyfloss, Roario, Swanana, Sweetooth, Syrupent, Tartridge and Twingersnap. This works on a Jameleon as well but you'll need to feed it an orchid as well for this to work.
In Pocket Paradise, Medicine will only make variants of Barkbark, Roario, and Swanana.
Amber · Banana Split · Blue Bone · Bone · Bread · Carrot Cake · Cheese · Cheesecake · Coffee · Diamond · Emerald · Figgy Pudding · Garlic Butter · Gold Flake · Gold Nugget · Gooseberry Fool · Green Bone · Honey · Horse Radish · Jack 'o' Lantern · Jam · Marmalade · Medicine · Milk · Mine Workings · Muffin · Mushroom · Peanut Butter · Rainbow Gem · Red Bone · Ribs · Ruby · Sandwich · Sapphire · Skull · Spine · Stew · Toffee Apple · Wool